Development of precise and efficient methods and technologies for creating new materials is at the forefront of chemical science and the focus of technology innovation. In this project, we will combine traditional synthesis and asymmetric catalysis to develop new asymmetric catalytic kinetic resolution reactions, methods and strategies. We will study the kinetic resolutions and dynamic kinetic resolutions in the catalytic asymmetric hydrogenation of esters, ketones and enones, aiming for efficient, green, and atomic economic synthesis of chiral alcohols, especially the chiral alcohols with multiple chiral centers. We will also study the applications of asymmetric catalytic kinetic resolution in the total syntheses of chiral drugs and bioactive natural products. Hopefully, this project will develop new processes for creating chiral materials, and promote the pharmaceutical industry.