At the invitation of the College of Life Sciences of Nankai University, Chen Zijiang, an academician of the Chinese Academy of Sciences and chair professor of Shandong University, gave an academic lecture entitled “Scientific Research on Major Needs for Reproductive Health” online on December 5. The head of the College of Life Sciences moderated the meeting.
Academican Chen Zijiang shared the ideas related to clinical research based on professional characteristics. First, starting with the standardized diagnosis and treatment of major reproductive diseases and clinical research, it identifies common problems from reproductive clinical practices, and strives to solve the problems facing assisted reproductive technology through multi-center randomized controlled trials (RCTs). The second RCT case is the frozen embryo transfer study of infertility patients with anovulatory disorders. A multicenter and large-sample RCT revealed that the use of frozen embryo transfer technology provides safer clinical outcomes compared with fresh embryo transfer, with a significant reduction in the risk of complications (down by 70%). The third RCT case is a frozen transfer study for a single blastocyst. A multicenter and large-sample RCT revealed that fresh single blastocyst transfer yielded a 28.8% increase in live birth rate and a significant reduction in the multiple birth rate. The fourth RCT case is the effect appraisal of PGT-A in conventional In Vitro Fertilization (IVF) patients. A multicenter and large-sample RCT conducted revealed that PGT-A reduced the cumulative live birth rate compared to conventional IVF patients, that the cumulative abortion rate was reduced but was insignificant, and that there is no difference in birth defect rate and other obstetric complications. This achievement can regulate the use of PGT-A and avoid the waste of medical resources.
In the Lecture, Chen Zijiang introduced how to conduct research on the mechanism of occurrence of major reproductive diseases and human embryonic development based on a series of studies performed by his group. The lecture also covered the technological innovation by medical workers and the work related to social services.
(Edited and translated by Nankai News Team)